CELL BIOLOGY
Corso
A Padova
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Descrizione
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Tipologia
Corso
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Luogo
Padova
The knowledge acquired by the student will be evaluated with a written exam organized in two parts.
First part (1 CFU) described in the course contents at section 1 will be assesed with one open question that include a long answer.
the second part (7 CFU) described in the course content at section 2 to 5 will be assessed with six questions that include short or longer answer.
The final grade is expressed as a weighted average between the two parties.
Sedi e date
Luogo
Inizio del corso
Inizio del corso
Opinioni
Programma
Lectures will cover 5 main topics:
1) In vitro cultures, methods for cellular molecular biology. Physical principles behind the most common microscopy techniques.
2) Chromatin Biology and nuclear organization to address fundamental questions in Epigenetics and Gene Regulation as well as in cellular differentiation and nuclear reprograming. Mechanisms of epigenetic regulation, including DNA methylation and post-translational modification of histones, and the roles of chromatin-assembly modifying complexes, non-coding RNAs and nuclear organization. X chromosome inactivation. Cell Memory and Genomic Imprinting. Centromeres and telomeres chromatin.
3) Main principles of autophagy and related diseases
4) Stem cell origins, plasticity and epigenetics. Bivalent Chromatin. Stem cell niche. Adult, Embryonic, and induced pluripotent Stem cells.
5) Signal transduction and cancer. Immortalization, role of telomeres. Malignant transformation, disturbances in signal transduction pathways resulting in malignant transformation, role of failure in signaling pathways regulating cellular proliferation, apoptosis and DNA-repair pathways. Cancer stem cells.
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Ti aiuterà a confrontare vari corsi e trovare l'offerta formativa più conveniente.
CELL BIOLOGY