GENOMICS
Corso
A Padova
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Descrizione
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Tipologia
Corso
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Luogo
Padova
The exam will be articulated into three parts: 1) a written session in which the student must describe the results of the laboratory practicals, that must be submitted at least one week before the official date of the exam, 2) a quiz session on Moodle, that will take place at the beginning of the day of the exam, 3) an oral discussion in which the student must describe his/her laboratory activity and answer questions on the topics of the course. A continuous process of assessment will be carried out throughout the course, to verify the level of understanding of the students.
Sedi e date
Luogo
Inizio del corso
Inizio del corso
Opinioni
Programma
Part 1.
Presentation of course and practicals
Introduction: Life, Biology, Information, Genomes, Evolution
History of genomics
Next Generation sequencing (NGS)
NGS: data formats for reads
Classical sequence alignment and assembly algorithms
NGS read alignment
Alignment formats: gff, sam and bam
Genome assembly with NGS data
Mate pair libraries and scaffolding
Metagenomics
Part 2
Transcriptome: Northern, EST, Full length, Microarrays
RNAseq
Analysis of RNAseq data
Proteomics
miRNA,
miRNA target prediction; lincRNA
Interactomics, and functional associations
Gene prediction, gene ontology and gene annotation
DNA methylation and methylome analysis
Histone modification and ChIP analysis"
Part 3
Analysis of human mutations and polymorphisms
GWAS
Genome re-sequencing and Exome sequencing
Personalized medicine and related bioinformatics
Genome browsers
Data integration and systems biology
General summary, discussion and conclusions
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GENOMICS